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The American Journal of Psychiatry, VOL. 151, No. 11

REGULAR ARTICLES | November 01, 1994

Central serotonergic hyperresponsivity in late-onset Alzheimer's disease

Am J Psychiatry 1994;151:1701-1703.

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Abstract

The prolactin response to oral d-fenfluramine (30 mg) was measured in nine patients with late-onset Alzheimer's disease and in an elderly comparison group. The serotonin-mediated prolactin response was significantly greater in the patients with Alzheimer's disease than in the comparison group. This finding suggests that central serotonin responsivity is greater in Alzheimer's disease.

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