Serotonergic function in 22 patients with primary dysthymia and 22
normal volunteers was evaluated by measuring [3H]serotonin uptake and
[3H]paroxetine binding in platelets. A significantly lower maximum rate of
serotonin uptake was noted in the dysthymic patients than in the normal
subjects, indicating a possible serotonergic dysfunction in dysthymia.
However, the values for parameters of paroxetine binding were similar in
the two groups.