Thirteen treatment-refractory schizophrenic patients (10 men and three
women) who were receiving more than 50 mg/day of haloperidol and who had
been hospitalized for more than 1 year successfully tolerated a mean dose
reduction of 63% with consequent improvement in psychopathology and side
effects. The addition of intensive behavior therapy to the optimal dose of
haloperidol yielded further improvements in functional behavior, such as
self-care and social interaction.