Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol
hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed
cortisol nonsuppression on the dexamethasone suppression test. Only four
patients exhibited both neuroendocrine abnormalities, demonstrating a lack
of association between these two neuroendocrine disturbances of over 50%.
Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died
during that period. Six of the eight surviving patients exhibited cortisol
hypersecretion without cortisol nonsuppression.