An informative way of dissecting the functional role of the risk SNP is to test its associations with brain structures using in vivo MRI methods. We recruited 278 unrelated healthy Han Chinese individuals without alcohol dependence, mental disorders, drug abuse, or brain injury. Structural images were acquired using a 3-T Philips MRI scanner, and a voxel-based morphometry method was used to provide voxel-wise assessment of volumetric difference. Detailed information about the sample, MRI acquisition, image preprocessing, and genotyping methods are provided in the data supplement that accompanies the online edition of this letter. The effect of the genotype was examined using a linear regression at each voxel, adjusting for age, gender, and intracranial volume. Voxel-wise p values were corrected over the brain to control family-wise error rate.