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The American Journal of Psychiatry, VOL. 150, No. 10

REGULAR ARTICLES | October 01, 1993

Tricyclic dose requirements across pregnancy

Am J Psychiatry 1993;150:1541-1542.

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Abstract

In a series of eight pregnant women, the authors found that the doses of tricyclic antidepressants required to achieve remission of symptoms and adequate serum levels increased during the second half of pregnancy. During the final trimester, the mean dose required was 1.6 times the mean dose required when the patients were not pregnant.

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