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The American Journal of Psychiatry, VOL. 150, No. 10

REGULAR ARTICLES | October 01, 1993

Long-term outcome of treatment-resistant depression in older adults

Am J Psychiatry 1993;150:1539-1540.

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Abstract

Seventeen elderly patients with treatment-resistant depression were reassessed 15 months and 4 years after treatment with an antidepressant agent or ECT. At 15 months 47% (seven of 15) were clinically improved, and at the 4-year follow-up 71% (10 of 14) were improved. These results indicate that treatment-resistant depression may improve over time because of either the natural course of the illness or persistent treatment efforts.

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