OBJECTIVE: The authors studied the effects of vitamin E treatment of
tardive dyskinesia; earlier studies have produced contradictory results.
METHOD: Twenty-eight patients with tardive dyskinesia were treated in a
double-blind, parallel-group comparison study of 8-12 weeks of treatment
with vitamin E (1600 IU/day) or matching placebo capsules. RESULTS: The
Abnormal Involuntary Movement Scale scores of the patients treated with
vitamin E improved significantly compared to the scores of the patients
given placebo. CONCLUSIONS: These results support earlier findings of the
efficacy of vitamin E in treating tardive dyskinesia.