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Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania
Am J Psychiatry 1993;150:1252-1254.
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Abstract

Membrane phospholipids were measured in platelets of seven medication- free patients in the manic phase of bipolar affective disorder and seven healthy comparison subjects. The relative percentage of platelet membrane phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic patients than in the comparison subjects. These results are consistent with an enhanced neuronal second messenger response after 5-hydroxytryptamine receptor stimulation followed by neurotransmitter release.

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