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The American Journal of Psychiatry, VOL. 150, No. 5

REGULAR ARTICLES | May 01, 1993

Ketoconazole administration in hypercortisolemic depression

Am J Psychiatry 1993;150:810-812.

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Abstract

Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.

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