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The American Journal of Psychiatry, VOL. 150, No. 4

Brief Reports | April 01, 1993

Limited therapeutic effect of addition of buspirone in fluvoxamine- refractory obsessive-compulsive disorder

Am J Psychiatry 1993;150:647-649.

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Abstract

The authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms. This finding suggests that addition of buspirone to ongoing fluvoxamine therapy is not an effective treatment strategy for most patients with obsessive- compulsive disorder.

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