Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Special Articles   |    
Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics
Am J Psychiatry 1992;149:1534-1538.
text A A A
PDF of the full text article.

OBJECTIVE: Meta-analysis was used to review the research literature on self-reported sensitivity to alcohol among sons of alcoholic and among normal control subjects. METHOD: Computerized and manual searches identified 17 eligible independent articles; nine contained the information necessary to compute effect sizes, and additional data on two other studies were provided by authors in response to written and telephone requests. RESULTS: Findings from 10 studies indicated that sons of alcoholics report significantly less sensitivity to alcohol than normal control subjects overall and during the ascending (i.e., 0- 35 minutes after alcohol) and descending (i.e., 40-240 minutes after alcohol) limbs of the blood alcohol curve. Response to placebo did not significantly distinguish these groups in the five studies that included such assessment. CONCLUSIONS: It may be appropriate to appraise the biological sons of male alcoholics that they may experience less subjective sensitivity to alcohol than other individuals, but it is not possible to predict whether any particular individual will experience such lower sensitivity. In addition, self- report data can be influenced by many factors, and further research that assesses multiple psychological and physiological measures and uses longitudinal designs is needed to determine the relationship between specific factors and the development of alcoholism.

Abstract Teaser
Figures in this Article


ethanol ; alcoholics
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Web of Science® Times Cited: 125

Related Content
APA Practice Guidelines > Chapter 0.  >
APA Practice Guidelines > Chapter 0.  >
APA Practice Guidelines > Chapter 0.  >
APA Practice Guidelines > Chapter 0.  >
Topic Collections
Psychiatric News
PubMed Articles