The situations in which the first panic attack occurred were
investigated in 44 patients affected by panic disorder. Although the first
panic attack was reported to be unexpected and no avoidance was present
before it, 75.8% of patients (N = 22) with panic disorder with agoraphobia
had their first panic attack in phobogenic situations, compared with 20% of
patients (N = 3) with panic disorder without agoraphobia.