Dr. Chaudron cites an important prospective study by Cohen et al. (3) demonstrating that women with a history of recurrent major depression who discontinued medication during pregnancy or just before conception had five times the risk of another episode of depression compared with women who continued medication during pregnancy. However, in a recent prospective study of pregnant women with a history of depression by Yonkers et al. (4), no differences were found in risk of another episode of depression among women who discontinued antidepressant treatment compared with women who did not. While methodological differences may account for these findings, the conflicting results are likely attributable to divergent populations under investigation. Individuals in the Cohen et al. study were recruited from psychiatric treatment centers and had more severe forms of depression, including early age at onset (<14 years) and comorbid psychiatric illness. Yonkers et al. recruited women from community- and hospital-based obstetric clinics. In both studies, women with at least four previous episodes of depression had a greater risk of relapse of depression during pregnancy, suggesting that those with more severe forms of the disorder are likely at greatest risk for relapse.