Twenty acutely manic patients were studied in a double-blind randomized
trial comparing verapamil with lithium. The Petterson Mania Scale, the
Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impression
(CGI) were administered before treatment and weekly during 4 weeks of
treatment to evaluate response to verapamil and lithium. Both treatment
groups improved significantly, and there were no significant overall
differences between treatments.