Eighteen outpatients with obsessive-compulsive disorder were treated
with either buspirone, a partial serotonin agonist, or clomipramine, a
serotonin uptake inhibitor, in a double-blind, random-assignment study.
Both drugs led to statistically significant and similar improvements in
scores on the Yale-Brown Obsessive-Compulsive Rating Scale and other
obsessive-compulsive and depression scales. This preliminary result
warrants further exploration with a larger sample and other serotonergic