The authors treated 19 adults with attention-deficit hyperactivity
disorder with an open trial of bupropion. These patients had received
maintenance stimulant medication or monoamine oxidase inhibitors for an
average of 3.7 years. Fourteen of the patients experienced moderate to
marked benefit from bupropion; ten of these patients chose to continue
bupropion rather than their former medication. These results suggest that
bupropion may be an alternative to stimulants in treating some adults with
attention-deficit hyperactivity disorder.