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Buspirone augmentation of fluoxetine in obsessive-compulsive disorder

Published Online:https://doi.org/10.1176/ajp.147.6.798

Eleven obsessive-compulsive patients underwent a prospective open-label trial of fluoxetine monotherapy followed by buspirone augmentation. The combination therapy was statistically superior to fluoxetine monotherapy. The results point to the importance of the 5-HT1a receptor in obsessive-compulsive disorder.

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