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The American Journal of Psychiatry, VOL. 147, No. 6

REGULAR ARTICLES | June 01, 1990

Buspirone augmentation of fluoxetine in obsessive-compulsive disorder

Am J Psychiatry 1990;147:798-800.

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Abstract

Eleven obsessive-compulsive patients underwent a prospective open-label trial of fluoxetine monotherapy followed by buspirone augmentation. The combination therapy was statistically superior to fluoxetine monotherapy. The results point to the importance of the 5-HT1a receptor in obsessive-compulsive disorder.

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