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Response to 35% CO2 as a marker of panic in severe anxiety

Published Online:https://doi.org/10.1176/ajp.147.6.796

One inhalation of 35% CO2 was administered to each of 32 patients with high anxiety ratings. Only patients with panic disorder had increases in reported anxiety upon CO2 intake. CO2-triggered anxiety appears specific for panic disorder and independent of baseline anxiety.

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