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Reduced dark-adaptation: an indication of lithium's neuronal action in humans
Am J Psychiatry 1990;147:629-631.
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Abstract

Although lithium plays a major role in therapy and prophylaxis of affective psychoses, no direct indication of its neuronal action in humans exists. A lithium-induced strong reduction of foveal dark- adaptation was found in healthy volunteers, and a lithium-induced reduction was also measured in patients with affective psychoses. Dark- adaptation measurements apparently offer the opportunity for in vivo monitoring of lithium's CNS effects in humans and may predict lithium's clinical efficacy.

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