Although lithium plays a major role in therapy and prophylaxis of
affective psychoses, no direct indication of its neuronal action in humans
exists. A lithium-induced strong reduction of foveal dark- adaptation was
found in healthy volunteers, and a lithium-induced reduction was also
measured in patients with affective psychoses. Dark- adaptation
measurements apparently offer the opportunity for in vivo monitoring of
lithium's CNS effects in humans and may predict lithium's clinical
efficacy.
Abstract Teaser