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Adjunctive imipramine maintenance treatment in schizophrenic patients with remitted postpsychotic depression

Published Online:https://doi.org/10.1176/ajp.146.11.1495

Ten patients with histories of postpsychotic depression responsive to adjunctive imipramine added to fluphenazine decanoate and benztropine underwent a double-blind trial of imipramine discontinuation 6 months after responding to the adjunctive imipramine. Discontinuation of imipramine was associated with depressive relapse.

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