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The American Journal of Psychiatry, VOL. 145, No. 10

REGULAR ARTICLES | October 01, 1988

Depression associated with nifedipine-induced calcium channel blockade

Am J Psychiatry 1988;145:1277-1279.

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Abstract

Four cases are reported in which substantial depression was associated with the use of the calcium channel blocker nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In each case, the depression resolved following discontinuation of nifedipine. Possible mechanisms by which nifedipine may influence affective states are discussed.

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