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The American Journal of Psychiatry, VOL. 145, No. 8

REGULAR ARTICLES | August 01, 1988

Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

Am J Psychiatry 1988;145:1015-1017.

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Abstract

Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive- compulsive disorder are discussed.

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