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Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings
Am J Psychiatry 1988;145:1015-1017.
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Abstract

Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive- compulsive disorder are discussed.

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