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Prolactin response to tryptophan during mianserin treatment

Published Online:https://doi.org/10.1176/ajp.145.6.740

Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5- hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.

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