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The American Journal of Psychiatry, VOL. 144, No. 10

REGULAR ARTICLES | October 01, 1987

Inadequate plasma concentrations in some high-dose methadone maintenance patients

Am J Psychiatry 1987;144:1349-1350.

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Abstract

The author studied 18 heroin addicts who had been maintained on 80 mg/day of methadone and who abused drugs or alcohol. His findings suggest that in some cases of aberrant methadone metabolism, the dose can be raised to achieve plasma concentrations adequate to eliminate drug and alcohol abuse.

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