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The American Journal of Psychiatry, VOL. 144, No. 10

REGULAR ARTICLES | October 01, 1987

Antipsychotic effect of buprenorphine in schizophrenia

Am J Psychiatry 1987;144:1340-1342.

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Abstract

The antipsychotic potency of the partial opiate agonist buprenorphine was evaluated in 10 neuroleptic-free schizophrenic patients suffering from frequent hallucinations, delusions, and severe formal thought disorders. Buprenorphine had a pronounced antipsychotic effect, which lasted about 4 hours, in patients with schizophreniform disorders (N = 4) and paranoid schizophrenia (N = 3).

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