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Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy [published erratum appears in Am J Psychiatry 1987 Nov;144(11):1521]

Published Online:https://doi.org/10.1176/ajp.144.9.1220

Cases of profound hypoglycemia after the initiation of tricyclic antidepressant therapy in two patients taking sulfonylureas are described. To the authors' knowledge, this is the first report of a potential drug interaction between tricyclic antidepressants and sulfonylureas.

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