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Emergence of depressive symptoms in patients receiving alprazolam for panic disorder
Am J Psychiatry 1987;144:664-665.
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Abstract

The authors relate their clinical experience with 46 panic disorder patients who were receiving 3-10 mg/day of alprazolam. Fifteen (33%) developed symptoms consistent with DSM-III criteria for major depression despite remission of their panic symptoms. Clinicians should be alert to this potentially reversible complication.

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