In a study of 19 manic patients, the authors found that eight suffered
from mixed mania, a condition in which depressive symptoms are found in the
context of classic manic features. The presence of a mixed manic state
predicted at least a slower and possibly a poor response to lithium
therapy. The authors suggest that the delineation of a subgroup of mixed
manic patients might help to identify potential lithium- resistant
patients.
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