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The American Journal of Psychiatry, VOL. 143, No. 12

REGULAR ARTICLES | December 01, 1986

Comparison of clonidine and lithium in the treatment of mania

Am J Psychiatry 1986;143:1608-1609.

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Abstract

The authors compared the antimanic effects of clonidine with lithium carbonate in a double-blind crossover design with 24 volunteers. Lithium was observed to be more effective than clonidine. Some patients reported experiencing hypotension (N=8) and depression (N=7) while taking clonidine.

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