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Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

Published Online:https://doi.org/10.1176/ajp.143.5.650

Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.

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