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The American Journal of Psychiatry, VOL. 143, No. 5

REGULAR ARTICLES | May 01, 1986

Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

Am J Psychiatry 1986;143:650-651.

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Abstract

Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.

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