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The American Journal of Psychiatry, VOL. 142, No. 11

REGULAR ARTICLES | November 01, 1985

Pharmacokinetic interaction of disulfiram and antidepressants

Am J Psychiatry 1985;142:1373-1374.

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Abstract

Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.

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