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Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia
Am J Psychiatry 1985;142:1106-1107.
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Abstract

In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.

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