Eight adolescents with major depressive disorder were treated with
nortriptyline and six adolescents with delusional depression were treated
with combined nortriptyline and chlorpromazine. Dose and plasma levels of
nortriptyline for the two groups were compared. The delusional group
receiving combined drug treatment needed significantly less nortriptyline
than did the nondelusional group receiving only nortriptyline to obtain
similar mean steady state plasma levels of the drug. The mean plasma
chlorpromazine levels were quite low.