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The norepinephrine-to-epinephrine ratio in patients with a history of suicide attempts
Am J Psychiatry 1985;142:224-227.
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Abstract

Norepinephrine and epinephrine were measured serially in 24-hour urine collections from 99 male psychiatric inpatients with mixed diagnoses. The group was blindly divided into those with a previous history of at least one suicide attempt (N = 38) and those without such a history (N = 61). The ratio of norepinephrine-to-epinephrine levels was significantly lower in the group with a history of suicide attempts. The authors discuss the possibility that a low norepinephrine-to- epinephrine ratio is a risk factor for suicidal behavior.

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