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The American Journal of Psychiatry, VOL. 141, No. 10

REGULAR ARTICLES | October 01, 1984

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome

Am J Psychiatry 1984;141:1287-1288.

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Abstract

A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma methadone level must be monitored.

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