The authors describe two patients with secondary mania associated with
right thalamic infarctions. Both patients exhibited hemisensory loss,
denial of illness, and amnesia for the manic episode. One improved with
lithium therapy and the other recovered without specific pharmacologic
intervention. A review of reported cases reveals that most focal lesions
associated with secondary mania involve the diencephalic region and that
the majority of lateralized lesions are on the right side.