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The American Journal of Psychiatry, VOL. 141, No. 4

REGULAR ARTICLES | April 01, 1984

CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients

Am J Psychiatry 1984;141:566-569.

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Abstract

Concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the lumbar CSF were measured in a group of suicidal schizophrenic patients and in a matched group of nonsuicidal schizophrenic patients. The suicidal group had a significantly lower level. This finding is consistent with reports of low levels of CSF 5-HIAA in suicidal patients with other psychiatric diagnoses and suggests that low CSF 5-HIAA may be a generalized marker of aggressive behavior against the self and others.

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