The presence of lateral ventricular enlargement in some manic-
depressive subjects, as assessed by ventricular-brain ratios (VBRs), has
been reported. A study of 27 bipolar patients and 27 individually matched
normal controls confirmed that finding. Bipolar patients had significantly
larger VBRs than did controls. Clinical measures associated with the
presence of ventricular enlargement in the bipolar patients included more
frequent hospitalizations and histories of persistent unemployment. Other
measures of illness severity or social deterioration were not significantly
associated with large VBR.
Abstract Teaser