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The American Journal of Psychiatry, VOL. 140, No. 9

REGULAR ARTICLES | September 01, 1983

Naloxone administration in obsessive-compulsive disorder: report of two cases

Am J Psychiatry 1983;140:1219-1220.

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Abstract

Two patients with obsessive-compulsive disorder experienced an exacerbation of chronic obsessional doubt after double-blind, placebo- controlled administration of naloxone. Endogenous opiates may be involved in the pathogenesis of this symptom.

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