The authors report on two fully right-handed men without prior
psychiatric history who developed mania secondary to vascular lesions of
the left and right hemispheres, respectively. One patient, whose left
hemisphere lesion produced a transient posterior aphasia, is believed to be
the first patient reported in the literature whose secondary mania followed
damage to the hemisphere documented to be dominant for both handedness and
speech. The authors conclude that it is premature to consider mania to a be
syndrome of the nondominant hemisphere.