A hypersexual pedophiliac sex offender was treated with the antiandrogen
medroxyprogesterone acetate for 500 days. During the treatment, his
testosterone blood levels significantly decreased, nearly to female values.
Pituitary gonadotropin and urinary steroid metabolite levels diminished
initially. Medroxyprogesterone therapy resulted in decreased libido, few
side effects, and no recurrence of sex offenses, but there was no change in
the patient's sexual orientation.