The authors studied CSF cortisol in 30 depressed patients, 10 manic
patients, 21 women with anorexia nervosa, and 22 normal control subjects.
All patients were also rated on a global severity scale for mania or
depression. Results indicated higher CSF cortisol levels in all three
patient groups than in the control group. Only the depressed group had a
significant positive correlation between CSF cortisol and severity ratings.
The authors recommend further research into the hypothalamic mechanisms
associated with cortisol secretion and regulation.