The authors studied the elimination of disulfiram and its metabolites
for 24 hours after disulfiram administration in five healthy male alcoholic
volunteers. Using high-performance liquid chromatography, they found that a
single 500-mg dose resulted in a gradual increase in plasma disulfiram and
its metabolites, with peak levels generally occurring 8 hours after dosing.
There was considerable interpatient variability (e.g., in one volunteer no
disulfiram was detected during the entire 24-hour sampling period). The
authors also found that breath carbon disulfide was 9.1% of the dose of
disulfiram administered, which is less than that expected
theoretically.
Abstract Teaser