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The American Journal of Psychiatry, VOL. 139, No. 11

REGULAR ARTICLES | November 01, 1982

Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients

Am J Psychiatry 1982;139:1460-1462.

An erratum to this article has been published | view the erratum

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Abstract

The authors tested working or recent memory in 24 stabilized schizophrenic outpatients who were taking psychotropic medication. Memory performance did not correlate with severity of schizophrenic symptoms, verbal IQ, or serum neuroleptic levels, but there was a significant inverse correlation between serum anticholinergic levels and performance on the memory task. The results suggest that therapeutic doses of anticholinergics may cause subtle impairments of cognitive functions.

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