Cognitive decline associated with old age and consistent with the
diagnosis of primary degenerative dementia is a unique clinical syndrome
with characteristic phenomena and progression. The authors describe a
Global Deterioration Scale for the assessment of primary degenerative
dementia and delineation of its stages. The authors have used the Global
Deterioration Scale successfully for more than 5 years and have validated
it against behavioral, neuroanatomic, and neurophysiologic measures in
patients with primary degenerative dementia.