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Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression

Published Online:https://doi.org/10.1176/ajp.139.8.1057

The authors conducted a double-blind, placebo-controlled clinical trial of the selective 5-HT reuptake inhibitor zimelidine in the treatment of major depressive illness. Zimelidine had the same antidepressant efficacy as amitriptyline but significantly fewer side effects, especially anticholinergic effects.

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