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"On-off" syndrome treated with lithium carbonate: a case report

Published Online:https://doi.org/10.1176/ajp.138.12.1626

The authors describe a 42-year-old man who developed "on-off" episodes and for whom lithium carbonate proved an effective treatment. They speculate that the predominant effect of lithium in the "on-off" syndrome is to prevent L-dopa desensitization of the dopamine receptor.

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